Physiological Functions of Pten in Mouse Tissues.
نویسندگان
چکیده
منابع مشابه
Physiological functions of Pten in mouse tissues.
PTEN is a tumor suppressor gene mutated in many human sporadic cancers and in hereditary cancer syndromes such as Cowden disease, Bannayan-Zonana syndrome and Lhermitte-Duclos disease. The major substrate of PTEN is PIP3, a second messenger molecule produced following PI3K activation induced by variety of stimuli. PIP3 activates the serine-threonine kinase PKB/Akt which is involved in anti-apop...
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ژورنال
عنوان ژورنال: Cell Structure and Function
سال: 2003
ISSN: 0386-7196,1347-3700
DOI: 10.1247/csf.28.11